The Analogues of original medicines (generics). How to save on medications?

If you've ever bought at the pharmacy drugs (and are there any who would not ever do that?), You might have noticed that in addition to the name of the drug, written in large letters that say, "from the heart", there are still one name written below, and type "thinner".

The first - is the trade or brand name. His choice is the prerogative of the manufacturer and is associated exclusively with the purpose of advertising, in order to totally implement in the minds of consumers its exclusive trademark. The second - an international non-proprietary name (INN), which gives the drug a special committee of the World Health Organization. It is not considered someone's property and is common to all products with the same composition.

Here is a good example: INN "Aspirin" corresponds to the mass of trade names, among which, of course, "aspirin", "Aspikor", "ASK-Cardio", "Cardi-ASA," etc. But this is not the most difficult for the average user. So, all brand names are divided into original products (brands) and generics. Let's see what it all means.

Brands and generics: how not to get lost in the two pines

The original drug or brand - is a drug that is made directly by the company-developer, ie, pharmaceutical company, which first showed the world an entirely new drug, conducted all the necessary stages of its study and testing. All original drugs after its opening covered by patent protection (for most countries, this period is 15-20 years old). Production of new drugs - very expensive event.

An eloquent example is the world-famous German pharmaceutical concern «Bayer» still can not cover its costs associated with the invention and development of its main creations - aspirin (acetylsalicylic acid). The cost of developing one (one!) The original drug is hundreds of millions of dollars. What can I say, if the leading French pharmaceutical company, "Servier" for 30 years, was able to register only 30 products.

The cost of developing one of the original drug is hundreds of millions of dollars!

Generics (a number of sources - generics or generic medicines) - are manufactured pharmaceutical factory under license from the company-developer, or after the expiration of patent protection. For generics put forward a much more sparing requirements in terms of studies, and register them unlike simpler than the original drug: the plant should only submit to the registering authority information about drug absorption performance compared to the original. It follows from this and the relatively low cost of generics. because plant, use already prepared clinical data do not have to bear the costs of long-term studies of the drug.

And if we continue the analogy with the "Servier", such as a large company we are able to establish an average production of 30 new generic drugs, but not for 30 years, and up to 1 year.

Total number of registered generic drugs in USA every year quite significantly increasing. At the same enalapril if scratched on the bottom of the barrel of domestic pharmacy counters, you can find more than 60 generic drugs, both domestic and foreign. At the same time it should be noted that the Russian producer focused mainly on the development of generics is.

Thus, among the hundred percent share of domestic brands over foreign drugs is only 3%. But among generics there is approximate parity: 52% domestic 48% foreign. It is obvious that the matter is that the notorious financial factor that does not allow our pharmaceutical industry "vbuhivat" millions of dollars to develop original products. It is much easier to write off from the more prosperous neighbor's party.

But too bad if generics compared to brands? We will try to answer this question.

Disadvantages of generics

In an ideal world, descended from the pages of books of Thomas More or Tomazzo Campanella, the generic must have proven therapeutic interchangeability with the brand. Perhaps this is true, but the fact that the information on this interoperability in most cases does not exist in nature.

Generic manufacturers just do not obliged to have them. Information about the pharmacokinetics in comparison with generic brand usually also omitted. There are only a few examples of the bargain publicity to this information, and even then, only in cases where the results were satisfactory.

In those rare cases when compared the clinical efficacy of brands and generics, the results were quite alarming. Thus, when comparing the hypotonic effect of a number of generic enalapril by observing the daily fluctuations in blood pressure were obtained quite heterogeneous information. In some cases, to achieve a similar brand pharmacological effect, required three times greater dose.

Since the production of generic pharmaceutical plants may use substances of diverse origin and quality and obsolete technology, low-cost packaging, etc., it is not surprising that the finished product may be different from the original drug in its "exterior", a combination of excipients , shape, pharmacokinetic or pharmacodynamic characteristics and, importantly, the degree of purification.

Invalid will say that all generics are completely substandard. GMP rules (a set of technical regulations for pharmaceutical production), by definition, must be observed in the production of both brands and generics. But notorious in the last degree of purification can be significantly lower, and other things being equal (active substance content) will play a generic brand for the pharmacological effect, and sometimes - very noticeable.

What are ordinary people must to do?

The main conclusion that you should take away from this article, the following: Generic - not necessarily worse than the brand, but that's better than him it can not be by definition. Therefore, if you have extra suitcase of money, as much as possible try to buy original drugs: so you will be fully confident in their pharmacological rear. If you're low on money, then opt for a mid-priced generics manufactured by major pharmaceutical companies. To navigate in the jungle of these drugs, it is recommended that you use the state register of medicines.

If you want to inquire about any medications, enter its name in the appropriate field. There you will see its trade name and the international nonproprietary name. As is known, now doctors are allowed to prescribe drugs only under the INN. Introducing the INN in the appropriate line, you can view all trade names corresponding to this INN. There you can find out information about the manufacturer and the drug.

All reputable names in the pharmaceutical world for a long time at the hearing, and bring them help in the cellar. If your finances are singing love songs, then nothing can be done: have to choose generic drugs made at factories capacities of developing countries, which, sadly, should also include our state, to say there is not the Minister of Health. For many of our plants are above GMP is a distant prospect, hence all the problems with the quality of our products.